CSF Aβ42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
CSF Aβ42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment
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DOI：
10.1212/01.wnl.0000156914.16988.56
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发表时间：
2005-04-12
期刊：
影响因子：
9.9
通讯作者：
Pirttilä, T
中科院分区：
文献类型：
--
作者：
Herukka, SK;Hallikainen, M;Pirttilä, T
测量了 46 名对照受试者和 78 名轻度认知障碍 (MCI) 患者的脑脊液淀粉样蛋白 β-肽-42 (A beta 42)、tau 和磷酸化 tau (P-tau) 基线水平。研究期间，23 名 MCI 患者出现痴呆。在阿尔茨海默病 (AD) 病程的早期就发现了异常的生物标志物。 MCI 患者中 AD 最具预测性的检测方法是 A beta 42 和 P-tau 的组合。
Baseline CSF amyloid beta-peptide-42 (A beta 42), tau, and phosphorylated tau (P-tau) levels from 46 control subjects and 78 patients with mild cognitive impairment (MCI) were measured. Twenty-three patients with MCI developed dementia during the study. Abnormal biomarkers were found early in the course of Alzheimer disease (AD). The most predictive assay for AD among the patients with MCI was the combination of A beta 42 and P-tau.