A bench top experimental model of bubble transport in multiple arteriole bifurcations
A bench top experimental model of bubble transport in multiple arteriole bifurcations
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DOI：
10.1016/j.ijheatfluidflow.2005.10.002
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发表时间：
2005-12-01
影响因子：
2.6
通讯作者：
Bull, JL
中科院分区：
文献类型：
--
作者：
Eshpuniyani, B;Fowlkes, JB;Bull, JL
受一种新的气体栓塞治疗技术的启发，利用台面血管分叉模型研究了一系列充液分叉中长气泡的破裂。发展中的气体栓塞术旨在通过使用气体栓子来治疗癌症，这些气体栓子是通过选择性地对血管内类似6微米的全氟碳液滴进行声学汽化而形成的。由此产生的气泡足够大，足以穿过几个血管分叉。目前的台式实验研究了重力和流动对气泡通过多个分叉的传输的影响。重力的影响可以通过改变分支网络围绕母管的滚动角来改变。当横摇角为零时，每个分叉处的分叉几乎是均匀的。结果表明，即使母管中的流量是恒定的，气泡也可以粘在第二代分叉处或第二代子管中。这项工作的结果表明，重力和流动在决定气泡运输方面都很重要，并表明包括多个剂量的治疗策略在将栓子输送到未被初始剂量阻塞的血管方面可能是有效的。(C)2005 Elsevier Inc.保留所有权利。
Motivated by a novel gas embolotherapy technique, a bench top vascular bifurcation model is used to investigate the splitting of long bubbles in a series of liquid-filled bifurcations. The developmental gas embolotherapy technique aims to treat cancer by infarcting tumors with gas emboli that are formed by selective acoustic vaporization of similar to 6 mu m, intravascular, perfluorcarbon droplets. The resulting gas bubbles are large enough to extend through several vessel bifurcations. The current bench top experiments examine the effects of gravity and flow on bubble transport through multiple bifurcations. The effect of gravity is varied by changing the roll angle of the bifurcating network about its parent tube. Splitting at each bifurcation is nearly even when the roll angle is zero. It is demonstrated that bubbles can either stick at one of the second bifurcations or in the second generation daughter tubes, even though the flow rate in the parent tube is constant. The findings of this work indicate that both gravity and flow are important in determining the bubble transport, and suggest that a treatment strategy that includes multiple doses may be effective in delivering emboli to vessels not occluded by the initial dose. (C) 2005 Elsevier Inc. All rights reserved.