A noninflammatory pathway for pregnancy loss: innate immune activation?
A noninflammatory pathway for pregnancy loss: innate immune activation?
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DOI：
10.1172/jci22258
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发表时间：
2004-07
期刊：
影响因子：
--
通讯作者：
J. Salmon
中科院分区：
文献类型：
--
作者：
J. Salmon
尽管免疫介导的妊娠丢失机制尚不清楚，但目前的研究主要集中在免疫激活和母胎界面组织损伤的介质上。然而，一项新的研究表明，全身性炎症介质可以通过不同的方式诱导妊娠失败，通过抑制卵巢激素的产生，并确定了免疫和生殖内分泌系统之间的联系。
Although the mechanisms of immune-mediated pregnancy loss are unknown, investigations are currently focused on mediators of immune activation and tissue injury at the maternal-fetal interface. A new study, however, demonstrates that systemic inflammatory mediators can induce pregnancy failure in a different way, by inhibiting ovarian hormone production, and identifies links between the immune and reproductive endocrine systems.