Mosquitoes do senesce: Departure from the paradigm of constant mortality
Mosquitoes do senesce: Departure from the paradigm of constant mortality
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DOI：
10.4269/ajtmh.2007.76.111
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Scott, Thomas W.
中科院分区：
文献类型：
--
作者：
Styer, Linda M.;Carey, James R.;Scott, Thomas W.
尽管几乎所有病媒传播疾病专家都认为死亡率的变化是节肢动物传播病原体能力的最重要决定因素之一，但操作上的假设往往是昆虫病媒死亡率与年龄无关。接受非衰老假设会导致错误的结论，蚊子的年龄是不重要的，结果在误导性的预测疾病减少后，病媒控制，并抑制研究蚊子生物学的其他方面，随着年龄的变化。我们采用大规模实验室生命表技术（N > 100，000）来研究登革热病毒的蚊子媒介埃及伊蚊的年龄依赖性死亡率问题。男女的死亡率均高度依赖于年龄。死亡率在幼年（< 10日龄）较低，在中年稳步上升，在老年下降。一个新的年龄相关的病原体传播模型表明，年轻的蚊子和人口年龄结构的重要性，传播动力学。从年龄无关的死亡率范式出发，鼓励对蚊子生物学中被忽视的复杂性进行研究，需要创新方法来研究蚊子种群动态，需要研究年龄相关的变化，以准确了解蚊子生物学和病原体传播。
Although variation in mortality is considered by virtually all vector-borne disease specialists to be one of the most important determinants of an arthropod's capacity to transmit pathogens, the operational assumption often is that insect vector mortality is independent of age. Acceptance of the non-senescence assumption leads to the erroneous conclusion that mosquito age is unimportant, results in misleading predictions regarding disease reductions after vector control, and represses study of other aspects of mosquito biology that change with age. We brought large-scale laboratory life table techniques (N > 100,000) to bear on the question of age-dependent mortality in the mosquito vector of dengue virus, Aedes aegypti. Mortality was highly age dependent in both sexes. Mortality was low at young ages (< 10 days old), steadily increased at middle ages, and decelerated at older ages. A newly derived age-dependent model of pathogen transmission shows the importance of young mosquitoes and population age structure to transmission dynamics. Departure from the age-independent mortality paradigm encourages research on overlooked complexities in mosquito biology, the need for innovative methods to study mosquito population dynamics, and the need to study age-dependent changes for an accurate understanding of mosquito biology and pathogen transmission.