Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP
Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP
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DOI：
10.1016/s0165-0270(01)00425-3
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发表时间：
2001-10-15
影响因子：
3
通讯作者：
Durif, F
中科院分区：
文献类型：
--
作者：
Chassain, C;Eschalier, A;Durif, F
目前最好的帕金森病模型是用1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）治疗的灵长类动物。动物运动的量化对于研究MPTP诱导的帕金森综合征的严重程度和对药物治疗的反应是重要的。两者都需要临床评定量表，以明确定义的客观项目来测量运动行为。然而，使用这些量表的评价取决于观察者根据他/她的经验对不同项目进行评分。视频图像分析仪系统，它产生的活动曲线与动物运动行为的视觉研究，提供了一种自动评估方法，是独立的和可重复的。使用这样一个系统，我们定义的项目与临床评定量表中使用的那些敏感的动物运动变化，减少运动与MPTP中毒和减轻左旋多巴：全球运动活动和特定的活动（攀登，社会交往，饮食行为）。(C)出版社：Elsevier Science B. V.
The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors). (C) 2001 Published by Elsevier Science B.V.