Health-related quality of life of significant others of patients with malignant CNS versus non-CNS tumors: a comparative study
Health-related quality of life of significant others of patients with malignant CNS versus non-CNS tumors: a comparative study
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DOI：
10.1007/s11060-013-1198-z
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发表时间：
2013-10-01
影响因子：
3.9
通讯作者：
Klein, Martin
中科院分区：
文献类型：
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作者：
Boele, Florien W.;Heimans, Jan J.;Klein, Martin
通常认为，由于神经和认知功能的进行性变化，脑肿瘤患者的重要他人（SO：伴侣，其他家庭成员或亲密朋友）可能比不涉及中枢神经系统（CNS）的恶性肿瘤患者面临更大的压力。我们比较了高级别胶质瘤（HGG）和低级别胶质瘤（LGG）患者SO的健康相关生活质量（HRQOL）与具有相似预后和疾病轨迹相似阶段的非CNS肿瘤患者SO的健康相关生活质量（HRQOL）（即分别为非小细胞肺癌（NSCLC）和低级别血液恶性肿瘤（NHL/CLL））。使用SF-36健康调查简表评估SO和患者的HRQOL。对患者的神经功能进行了索引，并对他们进行了全面的神经认知测试。213例LGG患者、99例NHL/CLL患者、55例HGG患者和29例NSCLC患者的SO参与。LGG和NHL/CLL患者的SO报告了相似的HRQOL水平。HGG患者的SO报告的心理健康评分（MCS; p = 0.041）和社会功能（p = 0.028）显著低于NSCLC患者。HGG和NSCLC患者的心理健康评分（MCS）与其SO的心理健康显著相关（分别为p = 0.013和p < 0.001）。令人惊讶的是，HGG患者的认知和神经功能在多变量水平上不能预测SO的心理健康。与未累及CNS且预期寿命相当的全身性肿瘤患者相比，急性期高度恶性CNS肿瘤患者的SO的HRQOL受损风险增加。
It is often assumed that brain tumor patients' significant others (SOs: partners, other family members or close friends) may face greater stress than those of patients with malignancies not involving the central nervous system (CNS), due to progressive changes in neurological and cognitive functioning. We compared health-related quality of life (HRQOL) of SOs of patients with high-grade glioma (HGG) and low-grade glioma (LGG) with that of SOs of patients with non-CNS tumors with similar prognosis and at a similar phase in the disease trajectory (i.e. non-small cell lung cancer (NSCLC) and low-grade hematological malignancies (NHL/CLL), respectively). HRQOL of SOs and patients was assessed using the Short Form-36 (SF-36) Health Survey. Patients' neurological functioning was indexed and they underwent comprehensive neurocognitive testing. SOs of 213 LGG patients, 99 NHL/CLL patients, 55 HGG patients and 29 NSCLC patients participated. The SOs of LGG and NHL/CLL patients reported similar levels of HRQOL. SOs of HGG patients reported significantly lower mental health scores (MCS; p = 0.041) and social functioning (p = 0.028) than those of NSCLC patients. Mental health scores (MCS) of HGG and NSCLC patients were associated significantly with the mental health of their SOs (p = 0.013 and p < 0.001, respectively). Surprisingly, HGG patients' cognitive and neurological functioning were not predictive of SOs' mental health at the multivariate level. SOs of patients with highly malignant CNS tumors in the acute phase are at increased risk of compromised HRQOL compared to those of patients with systemic tumors without CNS involvement and a comparable life expectancy.