IDENTIFICATION OF INTERLEUKIN-6 (IL-6) EXPRESSING NEURONS IN THE CEREBELLUM AND HIPPOCAMPUS OF NORMAL ADULT-RATS
IDENTIFICATION OF INTERLEUKIN-6 (IL-6) EXPRESSING NEURONS IN THE CEREBELLUM AND HIPPOCAMPUS OF NORMAL ADULT-RATS
复制标题
DOI：
10.1016/0304-3940(94)90807-9
复制
发表时间：
1994-12-05
影响因子：
2.5
通讯作者：
OTTEN, U
中科院分区：
文献类型：
--
作者：
GADIENT, RA;OTTEN, U
脑中白细胞介素-6（IL-6）的细胞来源尚未确定。用一种敏感的、非放射性的原位杂交技术，对IL-6 mRNA在大鼠脑不同区域的细胞定位进行了分析。浦肯野细胞和海马神经元IL-6 mRNA表达较强。我们的数据支持IL-6对小脑和海马神经元分化和功能的重要作用。
The cellular source of interleukin-6 (IL-6) in brain has not been identified. Using a sensitive, non-radioactive in situ hybridization technique, the cellular localization of IL-6 mRNA in different areas of the rat brain was analysed. Intense staining for IL-6 mRNA was found in Purkinje cells and hippocampal neurons. Our data support an essential role of IL-6 for cerebellar and hippocampal neuron differentiation and function.