STAM2, a new member of the STAM family, binding to the Janus kinases
STAM2, a new member of the STAM family, binding to the Janus kinases
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DOI：
10.1016/s0014-5793(00)01760-9
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发表时间：
2000-07-14
期刊：
影响因子：
3.5
通讯作者：
Sugamura, K
中科院分区：
文献类型：
--
作者：
Endo, K;Takeshita, T;Sugamura, K
我们在这里克隆了编码STAM2的cDNA，STAM2是STAM家族的新成员，包含SH3结构域和ITAM，STAM2像STAM1一样与Jak2和Jak3相关，并参与IL-2和GM-CSF介导的DNA合成和c-myc诱导的信号传导。 STAM1 和 STAM2 的 SH3 缺失突变体的 Go 表达在用 IL-2 和 GM-CSF 刺激时诱导抑制 DNA 合成的附加效应，表明在用 GM-SCF 和 IL-2 刺激时，STAM1 和 STAM2 分别对 Jak2 和 Jak3 下游的信号通路表现出补偿作用，(C) 2000 年欧洲生化会联合会。由 Elsevier Science B.V. 出版。保留所有权利。
We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM, STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Go-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.