Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials
Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials
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DOI：
10.1002/advs.202305918
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发表时间：
2023-12
期刊：
影响因子：
15.1
通讯作者：
Peng Yang;Y. Lu;Weiming Gou;Yiming Qin;Jianglin Tan;Gaoxing Luo;Qing Zhang
中科院分区：
文献类型：
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作者：
Peng Yang;Y. Lu;Weiming Gou;Yiming Qin;Jianglin Tan;Gaoxing Luo;Qing Zhang
糖胺聚糖（Glycosaminoglycans，GAG）对细胞外基质（extracellular matrix，ECM）内信号分子的产生和微环境的维持具有重要作用。已广泛探索了GAG和基于GAG的生物材料方法，以通过调节伤口微环境、加速上皮再形成和控制ECM重塑来促进原位组织再生和修复。然而，大多数方法对于临床应用仍然是不可接受的。为了提高对材料设计和临床转化应用的认识，本文综述了天然GAG在原位伤口愈合过程中的固有作用和生物活性机制，并介绍了常见的基于GAG的生物材料和促进伤口愈合的应用场景的适应性。此外，共享了基于GAG的生物材料广泛商业化之前的挑战，以确保未来设计和构建的基于GAG的人工生物材料更有可能重现人体组织中天然GAG表达的独特和组织特异性特征。这篇综述为研究人员设计仿生材料提供了一个更明确和清晰的选择指南，这些仿生材料将在某些功能上类似或超过天然材料，从而适合特定的环境或治疗目标。
Glycosaminoglycans (GAGs) are important for the occurrence of signaling molecules and maintenance of microenvironment within the extracellular matrix (ECM) in living tissues. GAGs and GAG‐based biomaterial approaches have been widely explored to promote in situ tissue regeneration and repair by regulating the wound microenvironment, accelerating re‐epithelialization, and controlling ECM remodeling. However, most approaches remain unacceptable for clinical applications. To improve insights into material design and clinical translational applications, this review highlights the innate roles and bioactive mechanisms of native GAGs during in situ wound healing and presents common GAG‐based biomaterials and the adaptability of application scenarios in facilitating wound healing. Furthermore, challenges before the widespread commercialization of GAG‐based biomaterials are shared, to ensure that future designed and constructed GAG‐based artificial biomaterials are more likely to recapitulate the unique and tissue‐specific profile of native GAG expression in human tissues. This review provides a more explicit and clear selection guide for researchers designing biomimetic materials, which will resemble or exceed their natural counterparts in certain functions, thereby suiting for specific environments or therapeutic goals.