Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
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DOI：
10.1101/gad.215802
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发表时间：
2002-01-15
影响因子：
10.5
通讯作者：
Wegner, M
中科院分区：
文献类型：
--
作者：
Stolt, CC;Rehberg, S;Wegner, M
Sox10是早期神经嵴高流动性组转录调控因子。没有Sox10，整个周围神经系统就没有胶质细胞发育。在这里，我们发现Sox10在中枢神经系统中仅限于髓磷脂形成的少突胶质细胞。在sox10缺陷小鼠中，祖细胞发育，但终末分化被破坏。在将缺乏sox10的神经干细胞移植到野生型宿主后，没有产生髓磷脂，这表明该缺陷具有永久性、细胞自主的性质。Sox10直接调控髓磷脂基因在少突胶质细胞中的表达，但不像在外周胶质细胞中那样调控erbB3的表达。因此，Sox10在不同的阶段和通过不同的机制在外周和中枢胶质细胞中起作用。
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.