Discovery of herpesviruses in bats
Discovery of herpesviruses in bats
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DOI：
10.1099/vir.0.83045-0
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发表时间：
2007-10-01
影响因子：
3.8
通讯作者：
Ehlers, Bernhard
中科院分区：
文献类型：
--
作者：
Wibbelt, Gudrun;Kurth, Andreas;Ehlers, Bernhard
利用泛疱疹病毒PCR方法，在欧洲7种不同的蝙蝠（翼翅目，蝙蝠科）中发现了7种针对DNA聚合酶（DPOL）基因的新型γ疱疹病毒（GHV）和1种新型β疱疹病毒（betaherpesvirus）。六种蝙蝠GHV的序列与伽马疱疹病毒属、穿透病毒和rhadinvirus的成员相似。第7株GHV与猪嗜淋巴疱疹病毒1型（马病毒属）有关。乙型疱疹病毒似乎是人类巨细胞病毒的远亲。对3只蝙蝠GHV扩增出3.6 kbp位点并测序，该位点横跨部分糖蛋白B基因和大部分DPOL基因。在系统发育分析中，这三种蝙蝠GHV形成了一个独立的分支，与穿透病毒和rhadinvirus分支的距离相似。这些新型病毒是首次在蝙蝠身上发现的疱疹病毒。
Seven novel gammaherpesviruses (GHV) and one novel betaherpesvirus were discovered in seven different European bat species (order Chiroptera, family Vespertilionidae) with a pan-herpesvirus PCR assay, targeting the DNA polymerase (DPOL) gene. The sequences of six bat GHV were similarly related to members of the gammaherpesvirus genera Percavirus and Rhadinovirus. The seventh GHV was related to the porcine lymphotropic herpesvirus 1 (genus Macavirus). The betaherpesvirus appeared to be a distant relative of human cytomegalovirus. For three bat GHV a 3.6 kbp locus was amplified and sequenced, spanning part of the glycoprotein B gene and the majority of the DPOL gene. In phylogenetic analysis, the three bat GHV formed a separate clade with similar distance to the Percavirus and Rhadinovirus clades. These novel viruses are the first herpesviruses to be described in bats.