Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity
Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity
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DOI：
10.1007/s10803-008-0636-9
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发表时间：
2009-03-01
影响因子：
3.9
通讯作者：
Posey, David J.
中科院分区：
文献类型：
--
作者：
Jahromi, Laudan B.;Kasari, Connie L.;Posey, David J.
本报告通过对RUPP自闭症网络数据的二次分析，研究了哌醋甲酯对广泛性发育障碍和多动儿童社交和自我调节的影响。参与者是33名年龄在5至13岁之间的儿童（29名男孩），他们参加了为期四周的安慰剂和增加剂量的哌醋甲酯的交叉试验，随机顺序各一周。每周对儿童的社会交往、自我调节和情感行为的某些方面进行观察测量。哌醋甲酯对儿童使用联合注意力启动、对联合注意力投标的反应、自我调节和调节情感状态有显著的积极影响。结果超越了最近的文献，并表明哌甲酯可能对PDD和多动儿童的社会行为产生积极影响。
This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.