Oral contraceptives alter sleep and raise body temperature in young women
Oral contraceptives alter sleep and raise body temperature in young women
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DOI：
10.1007/s004240100582
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发表时间：
2001-08-01
影响因子：
4.5
通讯作者：
Driver, HS
中科院分区：
文献类型：
--
作者：
Baker, FC;Mitchell, D;Driver, HS
雌性生殖类固醇，雌激素和黄体酮，不仅影响生殖功能，还影响体温调节和睡眠。长期服用合成类固醇，如口服避孕药的妇女，对这些调节系统的影响可能不同于内源性雌激素和黄体酮。因此，我们调查了服用口服避孕药的10名年轻女性的体温和睡眠，她们分别处于避孕药的有效期和安慰剂期，并将她们与处于卵泡中期和黄体中期排卵周期的9名女性进行了比较。与卵泡期相比，服用口服避孕药的妇女在活跃期和自然循环的妇女在黄体期的体温在24小时内升高。然而，在安慰剂阶段服用口服避孕药的女性，体温继续升高，与活跃阶段的女性相似，这表明合成生殖类固醇对体温的作用延长了。睡眠也受到内源性和合成生殖类固醇的影响，但与体温无关。服用口服避孕药的女性在活跃阶段有更多的第二阶段非快速眼动睡眠，与安慰剂期和自然周期的女性相比都是如此。然而，与服用避孕药的女性相比，自然月经周期的女性在黄体期有更多的慢波睡眠。因此，外源性生殖类固醇对体温和睡眠的影响不同于内源性黄体酮和雌激素。
Female reproductive steroids, oestrogen and progesterone, not only affect reproductive function, but also thermoregulation and sleep. Chronic administration of synthetic steroids, as occurs in women taking oral contraceptives, may affect these regulatory systems differently from endogenous oestrogen and progesterone. We therefore investigated body temperature and sleep in ten young women taking oral contraceptives, in the active and placebo phases of the contraceptive pack, and compared them to a group of nine women with ovulatory cycles, in the mid-follicular and mid-luteal phases. Body temperature was raised throughout 24 h in the women taking oral contraceptives in the active phase, and in the naturally cycling women in the luteal phase, compared to the follicular phase. The women taking oral contraceptives in the placebo phase, however, continued to have raised body temperatures, similar to those in the active phase, indicating a prolonged action of synthetic reproductive steroids on body temperature. Sleep also was influenced by the endogenous and synthetic reproductive steroids, but independently of body temperature. The women taking oral contraceptives had more stage-2 nonrapid eye movement sleep in the active phase, both compared to their placebo phase and the naturally cycling women. The naturally cycling women, however, had more slow wave sleep in the luteal phase compared to the contraceptive group of women. Exogenous reproductive steroids therefore influence body temperature and sleep differently from endogenous progesterone and oestrogen.