Biomarkers Linking PCB Exposure and Obesity
Biomarkers Linking PCB Exposure and Obesity
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DOI：
10.2174/1389201015666141122203509
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发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Dutta, Sisir K.
中科院分区：
文献类型：
--
作者：
Ghosh, Somiranjan;Murinova, Lubica;Dutta, Sisir K.
最近，肥胖症在世界大部分地区的流行程度急剧上升。肥胖作为一种复杂的、多因素的疾病，其健康后果可能是环境、遗传和行为因素相互作用的结果。有几条证据支持这样一种理论，即肥胖是在发育早期编程的，环境暴露可能起到关键作用。因此，我们假设，目前的疫情可能与化学物质暴露对基因控制的发育途径的影响有关，从而导致代谢紊乱。一些环境化学物质，如多氯联苯和农药残留，广泛存在于食品、饮用水和土壤中，它们对细胞过程产生多种影响，包括雌激素；一些已被证明影响肥胖、胰岛素抵抗、2型糖尿病和代谢综合征的发展。为了将这些证据汇集在一起并解决一个重要的健康问题，这一叙述性审查主要是为了解决与人类疾病，特别是肥胖有关的多氯联苯暴露，并评估多氯联苯对高暴露人群基因表达的影响。这一结果强烈表明，有必要对多氯联苯相关疾病的具体机制进行进一步研究。
Recently the prevalence of obesity has increased dramatically across much of the world. Obesity, as a complex, multifactorial disease, and its health consequences probably result from the interplay of environmental, genetic, and behavioral factors. Several lines of evidence support the theory that obesity is programmed during early development and that environmental exposures can play a key role. We therefore hypothesize that the current epidemic might associated with the influence of chemical exposures upon genetically controlled developmental pathways, leading to metabolic disorders. Some environmental chemicals, such as PCBs and pesticide residues, are widespread in food, drinking water, soil, and they exert multiple effects including estrogenic on cellular processes; some have been shown to affect the development of obesity, insulin resistance, type 2 diabetes, and metabolic syndrome. To bring these lines of evidence together and address an important health problem, this narrative review has been primarily designed to address PCBs exposures that have linked with human disease, obesity in particular, and to assess the effects of PCBs on gene expression in a highly-exposed population. The results strongly suggest that further research into the specific mechanisms of PCBs-associated diseases is warranted.