Combination of Light and Melatonin Time Cues for Phase Advancing the Human Circadian Clock
Combination of Light and Melatonin Time Cues for Phase Advancing the Human Circadian Clock
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DOI：
10.5665/sleep.3110
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发表时间：
2013-11-01
期刊：
影响因子：
5.6
通讯作者：
Wright, Kenneth P., Jr.
中科院分区：
文献类型：
--
作者：
Burke, Tina M.;Markwald, Rachel R.;Wright, Kenneth P., Jr.
研究目标：光刺激和非光刺激已被证明可以改变人体生物钟的相位。我们通过评估一晚服用外源性褪黑激素（单独服用或与早晨强光照射相结合）的相位提前效果，研究了人类昼夜节律系统如何将光和非光时间线索结合起来。设计：随机安慰剂对照双盲昼夜节律方案。通过唾液暗光褪黑激素起始（DLMO）的变化来评估四种条件的影响，即暗光（类似于1.9勒克斯，类似于0.6瓦/米（2））-安慰剂，暗光-褪黑激素（5毫克），亮光（类似于3000勒克斯，类似于7瓦/米（2））-安慰剂，以及亮光-褪黑激素对昼夜节律的影响。在恒定的常规条件下治疗之前和之后。在习惯性就寝时间前 5.75 小时给予褪黑激素或安慰剂，并在习惯性起床时间前 1 小时开始接受 3 小时的强光照射。环境：没有时间线索的睡眠和时间生物学实验室环境。参与者：36 名健康参与者（18 名女性），年龄 22 +/- 4 岁（平均值 +/- SD）。结果：早晨强光与傍晚外源性褪黑激素相结合诱导了更大的相位提前。 DLMO 优于单独治疗。单独的亮光和单独的褪黑激素会引起类似的相位提前。结论：来自光和褪黑激素的信息似乎由人类生物钟结合在一起。结合昼夜节律时间线索的能力对于理解人类昼夜节律计时系统的基本生理原理具有重要意义。了解这些原理对于设计有效的对策来调整人类生物钟的相移以适应时差、轮班工作以及设计针对昼夜节律睡眠觉醒障碍的有效治疗方法非常重要。
Study Objectives: Photic and non-photic stimuli have been shown to shift the phase of the human circadian clock. We examined how photic and non-photic time cues may be combined by the human circadian system by assessing the phase advancing effects of one evening dose of exogenous melatonin, alone and in combination with one session of morning bright light exposure.Design: Randomized placebo-controlled double-blind circadian protocol. The effects of four conditions, dim light (similar to 1.9 lux, similar to 0.6 Watts/m(2))-placebo, dim light-melatonin (5 mg), bright light (similar to 3000 lux, similar to 7 Watts/m(2))-placebo, and bright light-melatonin on circadian phase was assessed by the change in the salivary dim light melatonin onset (DLMO) prior to and following treatment under constant routine conditions. Melatonin or placebo was administered 5.75 h prior to habitual bedtime and 3 h of bright light exposure started 1 h prior to habitual wake time.Setting: Sleep and chronobiology laboratory environment free of time cues.Participants: Thirty-six healthy participants (18 females) aged 22 +/- 4 y (mean +/- SD).Results: Morning bright light combined with early evening exogenous melatonin induced a greater phase advance of the DLMO than either treatment alone. Bright light alone and melatonin alone induced similar phase advances.Conclusion: Information from light and melatonin appear to be combined by the human circadian clock. The ability to combine circadian time cues has important implications for understanding fundamental physiological principles of the human circadian timing system. Knowledge of such principles is important for designing effective countermeasures for phase-shifting the human circadian clock to adapt to jet lag, shift work, and for designing effective treatments for circadian sleep-wakefulness disorders.