Myo1c is designed for the adaptation response in the inner ear
Myo1c is designed for the adaptation response in the inner ear
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DOI：
10.1038/sj.emboj.7600169
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发表时间：
2004-04-07
期刊：
影响因子：
11.4
通讯作者：
Coluccio, LM
中科院分区：
文献类型：
--
作者：
Batters, C;Arthur, CP;Coluccio, LM
分子马达Myo1c是肌球蛋白家族的一员，在脊椎动物组织中广泛表达。它存在于内耳毛细胞静纤毛的关键部位，并且对表达可被选择性抑制的突变Myo1c的转基因小鼠的研究表明，它是机械电转导缓慢适应的介质，而这种适应对平衡是必需的。在此，我们研究了Myo1c的结构、力学和生化特性，以深入了解这种分子马达是如何工作的。我们的研究结果支持一种模型，即Myo1c具有一种应变感应的ADP释放机制，这使其能够适应机械负荷。
The molecular motor, Myo1c, a member of the myosin family, is widely expressed in vertebrate tissues. Its presence at strategic places in the stereocilia of the hair cells in the inner ear and studies using transgenic mice expressing a mutant Myo1c that can be selectively inhibited implicate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for balance. Here, we have studied the structural, mechanical and biochemical properties of Myo1c to gain an insight into how this molecular motor works. Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.