Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.
Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.
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DOI：
10.1021/acs.iecr.5b01237
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发表时间：
2015-10-28
影响因子：
4.2
通讯作者：
Doyle FJ 3rd
中科院分区：
文献类型：
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作者：
Huyett LM;Dassau E;Zisser HC;Doyle FJ 3rd
通过对胰岛素输送（也称为人工胰腺（AP））应用闭环控制策略，可以大大改善 1 型糖尿病的治疗。在这项工作中，我们概述了使用腹膜内 (IP) 胰岛素输送和葡萄糖传感的完全植入式 AP 的设计。该设计过程利用 IP 空间提供的快速葡萄糖传感和胰岛素作用来调整具有胰岛素反馈的 PID 控制器，以提供安全有效的胰岛素输送。该控制器经过调整以满足稳健的性能和稳定性规格。引入了抗重置饱和策略，以防止大餐干扰后发生低血糖的危险下冲。最终的控制器设计在 78% 的时间内将血糖控制在 80–140 mg/dL 的严格范围内，并且没有发生低血糖。下一步是在动物模型中测试该控制器设计，以评估体内性能。
Treatment of type 1 diabetes mellitus could be greatly improved by applying a closed-loop control strategy to insulin delivery, also known as an artificial pancreas (AP). In this work, we outline the design of a fully implantable AP using intraperitoneal (IP) insulin delivery and glucose sensing. The design process utilizes the rapid glucose sensing and insulin action offered by the IP space to tune a PID controller with insulin feedback to provide safe and effective insulin delivery. The controller was tuned to meet robust performance and stability specifications. An anti-reset windup strategy was introduced to prevent dangerous undershoot toward hypoglycemia after a large meal disturbance. The final controller design achieved 78% of time within the tight glycemic range of 80–140 mg/dL, with no time spent in hypoglycemia. The next step is to test this controller design in an animal model to evaluate the in vivo performance.