Control of structure, morphology and property in electrospun poly (glycolide-co-lactide) non-woven membranes via post-draw treatments
Control of structure, morphology and property in electrospun poly (glycolide-co-lactide) non-woven membranes via post-draw treatments
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DOI：
10.1016/s0032-3861(03)00464-6
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发表时间：
2003-08-01
期刊：
影响因子：
4.6
通讯作者：
Chu, B
中科院分区：
文献类型：
--
作者：
Zong, XH;Ran, SF;Chu, B
近年来，电纺非织造生物可降解膜在生物医学领域的应用引起了人们的极大关注。本研究研究了电纺聚(乙交酯-丙交酯)(GA/LA：90：10，PLA10GA90)非织造膜经拉伸和热处理后的微观结构、形态和织构，以调整其降解和力学性能。电纺PLA10GA90膜结晶度较低。在未拉伸的情况下进行高温热处理时，薄膜的结晶度较高，具有明显的片层结构，但没有整体取向。拉伸和退火后，薄膜的结晶取向明显改善。随着延伸率的增加，取向度和拉伸强度增加。在体外降解过程中，相应的拉伸保留时间也从2天增加到12天。与原始膜相比，后拉伸和退火膜在孵化初期的降解速度较慢，但在两周后的降解速度较快。(C)2003爱思唯尔科学有限公司。保留所有权利。
Non-woven biodegradable membranes fabricated by electrospinning have recently attracted a great deal of attention for biomedical applications. In this study, microstructure, morphology and texture of electrospun poly(glycolide-co-lactide) (GA/LA: 90:10, PLA10GA90) non-woven membranes were investigated after post-draw and thermal treatments to tailor the degradation and mechanical properties. As-prepared electrospun PLA10GA90 membranes exhibited a low degree of crystallinity. When annealed at elevated temperatures without drawing, the membrane showed a higher degree of crystallinity with distinct lamellar structure but no overall orientation. The crystal orientation improved significantly when the membrane was drawn and annealed. As the elongation ratio increased, the degree of orientation and the tensile strength were increased. The corresponding tensile retention time was also increased from 2 to 12 days during in vitro degradation. Post-drawn and annealed membranes exhibited a slower degradation rate in the beginning of incubation, but a faster rate after two weeks of degradation when compared to as-spun membranes. (C) 2003 Elsevier Science Ltd. All rights reserved.