Role of mucus layers in gut infection and inflammation.
Role of mucus layers in gut infection and inflammation.
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DOI：
10.1016/j.mib.2011.11.002
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发表时间：
2012-02
影响因子：
5.4
通讯作者：
Hansson GC
中科院分区：
文献类型：
--
作者：
Hansson GC
肠粘液是一种有效的系统，通过促进细菌的清除和将细菌与上皮细胞分离，从而抑制炎症和感染，从而保护上皮细胞免受细菌的侵袭。结肠内粘液层的功能尤其重要，因为这解释了我们如何在肠道中藏匿大量细菌。粘液系统的主要成分是MUC2粘蛋白，它通过其巨大的网状聚合物来组织粘液。病原微生物反过来又开发了绕过这种组织良好的粘液保护系统的机制。
The intestinal mucus is an efficient system for protecting the epithelium from bacteria by promoting their clearance and separating them from the epithelial cells, thereby inhibiting inflammation and infection. The function of the colon inner mucus layer is especially important as this explains how we can harbor the large number of bacteria in our gut. The major component of this mucus system is the MUC2 mucin which organizes the mucus by its enormously large net-like polymers. Pathogenic microorganisms, in turn, have developed mechanisms for circumventing this well-organized mucus protective system.