Are neostriatal dopamine receptors co-localized?
Are neostriatal dopamine receptors co-localized?
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DOI：
10.1016/0166-2236(93)90103-s
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发表时间：
1993-08
影响因子：
15.9
通讯作者：
D. Surmeier;A. Reiner;M. Levine;M. A. Ariano
中科院分区：
文献类型：
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作者：
D. Surmeier;A. Reiner;M. Levine;M. A. Ariano
多巴胺在新纹状体中的突触后作用是由5种g蛋白偶联受体介导的。这些受体在新纹状体神经元中共定位的程度一直存在争议。这一争论对多巴胺能信号紊乱的治疗策略具有深远的影响，如帕金森病和精神分裂症。本文综述了支持和反对共定位的分子和细胞证据，包括来自单细胞mRNA扩增和孤立神经元补丁夹的新信息。结论是，这一证据在很大程度上与大多数新纹状体传出神经元中d1和d2家族功能重要受体的共定位一致。这一结论对新纹状体的并行处理模型具有重要意义。
The postsynaptic effects of dopamine in the neostriatum are mediated by five G-protein-coupled receptors. The extent to which these receptors are co-localized in neostriatal neurons has become controversial. This debate has far-reaching implications for treatment strategies in disorders of dopaminergic signaling, such as Parkinson's disease and schizophrenia. This review examines the molecular and cellular evidence for and against co-localization, including new information derived from single-cell mRNA amplification and patchclamping of isolated neurons. It is concluded that this evidence is largely consistent with co-localization of functionally significant receptors of the D1and D2families in the majority of neostriatal efferent neurons. This conclusion has important implications for parallel processing models of the neostriatum.