Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
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大鼠下丘脑、胰腺和视网膜中促甲状腺素释放激素样物质的个体发育模式：光剥夺的选择性效应。
DOI：
10.1073/pnas.77.7.4345
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发表时间：
1980
影响因子：
11.1
通讯作者：
Refetoff,S
中科院分区：
文献类型：
--
作者：
Martino,E;Seo,H;Lernmark,A;Refetoff,S
最近的观察表明，在大鼠胰岛和视网膜中存在促甲状腺激素释放激素样物质（TRH-LM）。其免疫学和生物学特性与合成促甲状腺激素释放激素（促甲状腺激素释放素）相同。本通讯涉及TRH-LM在大鼠胰腺和视网膜的个体发育相比，大鼠下丘脑。还研究了性别和暴露于恒定黑暗的影响。结果表明，TRH-LM浓度的异步变化发生在这些组织的出生后成熟过程中，推测是由器官特异性控制机制介导的-例如，光仅影响TRH-LM在视网膜中的积累。TRH-LM可能作为神经递质参与胰岛细胞功能的调节和视网膜光感受的发育。下丘脑TRH-LM的增加似乎与垂体-甲状腺分泌活动的发展平行，但下丘脑外TRH-LM的功能仍然是推测性的。
Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and in retina. Its immunological and biological properties are identical to those of synthetic thyrotropin-releasing hormone (thyroliberin). This communication deals with the ontogenesis of TRH-LM in rat pancreas and retina as compared to that of rat hypothalamus. Effects of sex and exposure to constant dark were also studied. Results show that asynchronous changes in the concentration of TRH-LM occur during the postnatal maturation of these tissues, presumably mediated by organ-specific control mechanisms--e.g., light affects only the accumulation of TRH-LM in the retina. TRH-LM may act as neurotransmitter in the regulation of pancreatic islet cell function and in the development of photo-reception in the retina. Increases in hypothalamic TRH-LM seem to parallel the development of the pituitary-thyroid secretory activity, but the function of extrahypothalamic TRH-LM remains speculative.