Neoplasia in patients with chronic renal failure on long-term dialysis.
Neoplasia in patients with chronic renal failure on long-term dialysis.
复制标题
长期透析慢性肾功能衰竭患者的肿瘤形成。
作者：
P. Miach;J. Dawborn;J. Xipell
在接受维持性透析的 67 名患者中（56 名接受血液透析，11 名接受腹膜透析），其中 47 名患者未接受任何形式的免疫抑制治疗，无论是与肾移植相关的免疫抑制治疗，还是作为其内在肾病治疗的一部分。 47 名患者中有 6 名 (12.8%) 被发现患有并非直接导致肾衰竭的恶性肿瘤。 2 名患者患有肾癌，2 名患者患有皮肤癌，1 名患者患有胃癌，1 名患者患有小肠类癌。这就提出了一个问题：长期透析导致的尿毒症延长是否可能通过增加长期免疫抑制尿毒症状态下的寿命而导致恶性肿瘤的发展。
Out of 67 patients accepted for maintenance dialysis (56 for hemodialysis and 11 for peritoneal dialysis) 47 had not received any form of immunosuppression either in connection with renal transplantation or as part of the therapy for their intrinsic renal disease. Six out of the 47 patients (12.8%) were found to have malignancies which were not directly causing their renal failure. Two patients had carcinomas of the kidney, 2 patients had skin cancers, 1 patient had a carcinoma of the stomach and 1 patient had a carcinoid tumour of the small intestine. This raises the question whether prolongation of uremia by long term dialysis may contribute to the development of malignancy by increasing longevity in the chronically immunosuppressed uremic state.