Preparation of chitosan/amino multiwalled carbon nanotubes nanocomposite beads for bilirubin adsorption in hemoperfusion.
Preparation of chitosan/amino multiwalled carbon nanotubes nanocomposite beads for bilirubin adsorption in hemoperfusion.
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DOI：
10.1002/jbm.b.33806
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Wenhui Zong;Jian Chen;Wenyan Han;Jie Chen;Yue Wang;Weichao Wang;Guanghui Cheng;L. Ou;
中科院分区：
文献类型：
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作者：
Wenhui Zong;Jian Chen;Wenyan Han;Jie Chen;Yue Wang;Weichao Wang;Guanghui Cheng;L. Ou;
壳聚糖-碳纳米管复合微球结合了壳聚糖在形成稳定的生物相容性框架方面的优点和碳纳米管提供纳米效应（高强度和高比表面积等）的优点。本研究采用相转化法制备了壳聚糖/氨基多壁碳纳米管（CS/AMWCNT）复合微球，其中CS和AMWCNT通过乙二醇二缩水甘油醚（EGDE）进行交联。通过BET、SEM、TGA和拉曼光谱对所制备的CS/AMWCNT纳米复合材料珠进行了表征，其表现出由于AMWCNT的掺入而增强的热稳定性。力学性能测试结果表明，与未改性壳聚糖珠相比，CS/AMWCNT复合珠的力学强度显著提高，破碎率从34.1%降低到0.67%。在PBS和BSA溶液中测量对胆红素的吸附容量，并且具有5wt%AMWCNT的CS/AMWCNT复合珠显示出比壳聚糖珠（在PBS中8.5mg/g和在BSA中4.2mg/g）高得多的对胆红素的吸附容量（在PBS中12.7mg/g和在BSA中7.6mg/g）。我们的纳米复合微球具有良好的血液相容性，作为一种有效的胆红素吸附剂在血液净化中具有很高的应用潜力。© 2016 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater，106 B：96-103，2018。
Chitosan-carbon nanotube composite beads combines the advantages of chitosan in forming a stable biocompatible framework and carbon nanotube that provide nanometer effects (high strength and high specific surface area etc.). In this study, chitosan/amino multiwalled carbon nanotubes (CS/AMWCNT) composite beads was prepared by phase-inversion method, in which CS and AMWCNT was crosslinked by ethylene glycol diglycidyl ether (EGDE). The CS/AMWCNT nanocomposite beads produced has been characterized by BET, SEM, TGA, and Raman spectroscopy which exhibited enhanced thermal stability due to the incorporation of AMWCNT. Mechanical test results showed that mechanical strength of the CS/AMWCNT composite beads was significantly enhanced when comparing to unmodified chitosan beads, the breakage percentage decreased from 34.1% to 0.67%. The adsorption capacity for bilirubin was measured in PBS and BSA solutions, and the CS/AMWCNT composite beads with 5 wt% AMWCNT showed much higher adsorption capacity (12.7 mg/g in PBS and 7.6 mg/g in BSA) to bilirubin than chitosan beads (8.5 mg/g in PBS and 4.2 mg/g in BSA). Our nanocomposite beads with excellent hemocompatibility has a high potential application in blood purification as an efficient adsorbent for bilirubin. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 96-103, 2018.