Sericin/Dextran Injectable Hydrogel as an Optically Trackable Drug Delivery System for Malignant Melanoma Treatment
Sericin/Dextran Injectable Hydrogel as an Optically Trackable Drug Delivery System for Malignant Melanoma Treatment
复制标题
丝胶/葡聚糖注射水凝胶作为光学可追踪药物递送系统用于恶性黑色素瘤治疗
DOI：
10.1021/acsami.6b00959
复制
发表时间：
2016-03-16
影响因子：
9.5
通讯作者：
Wang, Lin
中科院分区：
文献类型：
--
作者：
Liu, Jia;Qi, Chao;Wang, Lin
癌症化疗的严重副作用促使人们开发更好的药物输送系统。可注射水凝胶是一种有效的部位-靶向系统。对于大多数可注射水凝胶，一旦在体内释放，包括药物释放和降解在内的一些性质，对化疗效果和安全性至关重要，监测是具有挑战性的。开发一种具有体内实时无创可追踪性的有效癌症治疗的药物递送系统是非常必要的。虽然荧光染料被用于水凝胶的成像，但其细胞毒性限制了其应用。以蚕丝中的天然发光蛋白丝胶为原料，成功地合成了一种联氨类交联型丝胶/葡聚糖可注射水凝胶。该水凝胶具有生物降解性和生物相容性。它实现了大分子和小分子药物的高效载药和控制释放。值得注意的是，丝胶从这种水凝胶中发出的光致发光与其降解直接而稳定地相关，从而能够对剩余的药物进行长期的体内成像和实时监测。阿霉素水凝胶可显著抑制肿瘤生长：总之，这项工作证明了这种药物输送系统的有效性，以及这种基于丝胶的光学监测策略的体内有效性，为改进水凝胶设计以实现化疗的最佳效率和安全性提供了一种潜在的途径，可能广泛适用于其他药物输送系统。
Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most of injectable hydrogels, once delivered in vivo, some properties including drug release and degradation, which are critical to chemotherapeutic effects and safety, are challenging to monitor. Developing a drug delivery system for effective cancer therapy with in vivo real-time noninvasive trackability is highly desired. Although fluorescence dyes are used for imaging hydrogels, the cytotoxicity limits their applications. By using sericin, a natural photoluminescent protein from silk, we successfully synthesized a hydrazone cross-linked sericin/dextran injectable hydrogel. This hydrogel is biodegradable and biocompatibie. It achieves efficient drug loading and controlled release of both macromolecular and small molecular drugs. Notably, sericin's photoluminescence from this hydrogel is directly and stably correlated with its degradation, enabling long-term in vivo imaging and real-time monitoring of the remaining, drug. The hydrogel loaded with Doxorubicin significantly suppresses tumor growth: Together, the work demonstrates the efficacy of this drug delivery system, and the in vivo effectiveness of this sericin-based optical monitoring strategy, providing a potential approach for improving hydrogel design toward optimal efficiency and safety of chemotherapies, which may be widely applicable to other drug delivery systems.