Receptor for transferrin may be a "target" structure for natural killer cells.
Receptor for transferrin may be a "target" structure for natural killer cells.
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转铁蛋白受体可能是自然杀伤细胞的“目标”结构。
DOI：
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发表时间：
1983
影响因子：
11.1
通讯作者：
M. Greaves
中科院分区：
文献类型：
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作者：
L. Vodinelich;R. Sutherland;C. Schneider;R. Newman;M. Greaves
由单抗OKT9检测到的人转铁蛋白受体似乎在已知为自然杀伤(NK)细胞提供敏感靶点的细胞类型上有很好的表达。通过三个系列的实验研究了转铁蛋白受体被NK效应细胞识别的可能性：(I)分析对自然杀伤的敏感性与不同细胞系中转铁蛋白受体阳性细胞比例的相关性；(Ii)研究细胞系转铁蛋白受体表达水平与其竞争性抑制NK细胞识别和杀伤靶细胞K562的能力之间的关系；(Iii)比较亲和力纯化的转铁蛋白受体可溶性蛋白水解物片段与HLAA、B分子抑制自然杀伤效应的能力。这些数据表明，转铁蛋白受体可以为NK细胞提供一个“靶”结构。由于转铁蛋白受体在正常和恶性增殖细胞上普遍表达，这些观察结果对体内NK细胞的可能功能具有有趣的意义。
Human transferrin receptors detected by monoclonal antibody OKT9 appear to be well expressed on cell types known to provide sensitive targets for natural killer (NK) cells. The possibility that transferrin receptors are recognized by NK effector cells has been investigated by three series of experiments: (i) analysis of the correlation between sensitivity to natural killing and the proportion of transferrin receptor-positive cells in different cell lines, (ii) study of the relationship between levels of transferrin receptor expression in cell lines and their capacity to competitively inhibit recognition and killing of the target cell K562 by NK cells, and (iii) comparison of affinity-purified soluble proteolytic fragments of the transferrin receptor and HLA-A, -B molecules for their ability to inhibit the natural killing effect. The data indicate that the transferrin receptor can provide a "target" structure for NK cells. Because transferrin receptors are ubiquitously expressed on normal and malignant proliferating cells, these observations have interesting implications for the possible function of NK cells in vivo.