Tropoelastin Implants That Accelerate Wound Repair
Tropoelastin Implants That Accelerate Wound Repair
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DOI：
10.1002/adhm.201701206
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发表时间：
2018-05-23
影响因子：
10
通讯作者：
Weiss, Anthony S.
中科院分区：
文献类型：
--
作者：
Mithieux, Suzanne M.;Aghaei-Ghareh-Bolagh, Behnaz;Weiss, Anthony S.
介绍了一种新型的纯合成材料，可促进全层皮肤伤口的修复。活性成分是原弹性蛋白，并利用其促进新血管形成的能力及其细胞招募特性来加速伤口修复。该技术的关键是使用一种新型的基于热的稳定形式的人原弹性蛋白，其允许可调的再吸收。这种可植入材料有助于定制的插入物，其可以成形为伤口床，在那里它水合以形成适形的蛋白质水凝胶。在健康猪的伤口愈合、皮肤修复和成熟上皮再生程度方面证明了显著益处。该植入物与全厚和中厚皮肤移植物的初始联合治疗兼容。植入物的优越性，无菌绷带，商业水凝胶和真皮再生模板产品。在此基础上，提供了一种用于开放性伤口即时治疗的预制组织修复材料的新概念。
A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided.