Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterizing a special type of T-cell.
Malignant lymphoma of plasmacytoid T-cells. Morphologic and immunologic studies characterizing a special type of T-cell.
复制标题
浆细胞样 T 细胞恶性淋巴瘤。
DOI：
--
复制
发表时间：
1983
影响因子：
5.6
通讯作者：
K. Lennert
中科院分区：
文献类型：
--
作者：
H. Müller;H. Stein;G. Steinmann;K. Lennert
1958年，在人类淋巴结中发现了一种中等大小的细胞，并且发现每10例反应性增生中就有1例出现聚集性细胞。起初，它被解释为淋巴母细胞。随后，电镜检查显示细胞含有丰富的粗面内质网，并明显局限于淋巴结的t区。最近，用一组单克隆抗体可以分析由这些细胞组成的恶性淋巴瘤。结果表明，这些细胞为Leu-1+、OKT4+、Leu-3a+、HLA-DR+，对VIL-A1（抗ALL常见抗原）和克隆F8-11-13有弱反应，但对OKT3、OKT11、OKT8、细胞质免疫球蛋白、常见b细胞抗原和C3b受体均阴性。短期内，体外培养的淋巴瘤细胞对植物血凝素和白细胞介素2 （IL2）反应较弱，但不产生IL2。淋巴瘤细胞自发增殖率低（Ki-67+细胞约2%）。鉴于这些发现，提出了“浆细胞t细胞”这一术语。由于患者在诊断为恶性淋巴瘤3个月后出现了髓细胞白血病，因此提示这些细胞与髓系系统之间存在功能关系。
In 1958, a medium-sized cell was recognized in human lymph nodes and found to occur in clusters in about one out of every 10 cases of reactive hyperplasia. At first, it was interpreted as a lymphoblast. Later, electron-microscopic investigations revealed that the cell contained abundant rough endoplasmic reticulum and was apparently restricted to T-regions of lymph nodes. Recently, it was possible to analyze a malignant lymphoma uniformly composed of such cells with a panel of monoclonal antibodies. The cells proved to be Leu-1+, OKT4+, Leu-3a+, HLA-DR+, and weakly reactive with VIL-A1 (antibody to common ALL antigen) and clone F8-11-13, but negative for OKT3, OKT11, OKT8, cytoplasmic immunoglobulin, common B-cell antigen, and C3b receptors. Short-term, in vitro cultures of lymphoma cells showed weak responses to phytohemagglutinin and Interleukin 2 (IL2), but no IL2 production. Lymphoma cells had a low spontaneous proliferation rate (about 2% Ki-67+ cells). In view of these findings, the term "plasma-cytoid T-cell" is proposed. A functional relationship between these cells and the myeloid system was suggested because the patient developed a myelomonocytic leukemia 3 months after the diagnosis of malignant lymphoma was made.