A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping
A computational framework for investigating the feasibility of focusing light in biological tissue via photoacoustic wavefront shaping
复制标题
研究通过光声波前整形在生物组织中聚焦光的可行性的计算框架
DOI：
10.1117/12.2656075
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Bewick J
中科院分区：
文献类型：
--
作者：
Bewick J
光声（PA）波前整形（WFS; PAWS）可以使光聚焦在活体组织深处，增加生物医学光学技术的穿透深度。PAWS实验已经证明了通过刚性散射介质聚焦光。然而，在组织深处聚焦明显更具挑战性。为了研究这一挑战的规模，开发了相干光在组织中传播的计算模型，以模拟光通过PAWS的聚焦。为了证明该模型，它被用来模拟在800 µm厚的组织样介质中的聚焦。为了显示该模型的实用性，在不同的条件下重复聚焦，说明涉及不同空间分辨率的简化PAWS实验。正如预期的那样，更精细的空间分辨率导致更明亮的焦点。通过为研究PAWS提供一个模拟平台，这项工作可以为开发能够在组织中聚焦光线的系统铺平道路。
Photoacoustic (PA) wavefront shaping (WFS; PAWS) could allow focusing light deep in living tissue, increasing the penetration depth of biomedical optics techniques. PAWS experiments have demonstrated focusing light through rigid scattering media. However, focusing deep in tissue is significantly more challenging. To examine the scale of this challenge, a computational model of the propagation of coherent light in tissue was developed to simulate the focusing of light via PAWS. To demonstrate the model, it was used to simulate focusing in an 800 µm thick tissue-like medium. To show the utility of the model, the focusing was repeated in different conditions illustrative of simplified PAWS experiments involving different spatial resolutions. As expected, a finer spatial resolution led to a brighter focus. By providing a simulation platform for studying PAWS, this work could pave the way to developing systems that can focus light in tissue.
DOI：
10.1016/j.jqsrt.2017.05.010
发表时间：
2017-09-01
影响因子：
2.3
作者：
Egel, Amos;Pattelli, Lorenzo;Lemmer, Uli
通讯作者：
Lemmer, Uli
波前整形的高效全波模拟可通过生物组织聚焦光
DOI：
--
发表时间：
2022
期刊：
Biomedical optics
影响因子：
--
作者：
Jake A. J. Bewick;P. Munro;S. Arridge;J. Guggenheim
通讯作者：
J. Guggenheim