TRPCing around the hypothalamus.
TRPCing around the hypothalamus.
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DOI：
10.1016/j.yfrne.2018.05.004
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发表时间：
2018-10
影响因子：
7.4
通讯作者：
Rønnekleiv OK
中科院分区：
文献类型：
--
作者：
Kelly MJ;Qiu J;Rønnekleiv OK
除TRPC 2外，所有典型的瞬时受体电位通道（TRPC）都在下丘脑神经元中表达，并参与多种稳态功能。虽然已显示代谢型谷氨酸受体与皮质和皮质下脑区域中的TRPC通道激活偶联，但在下丘脑中，多种胺和肽能G蛋白偶联受体（GPCR）和生长因子/细胞因子受体与TRPC通道的激活相关，所述TRPC通道对于生殖、温度调节、唤醒和能量稳态至关重要。除了神经递质，循环激素如胰岛素和瘦素通过其同源受体激活POMC神经元中的TRPC通道。许多神经递质和激素的突触后效应在不同的生理状态下通过突触后神经元中TRPC通道的表达来调节。因此，TRPC通道不仅是神经递质的重要靶点，也是循环激素在控制下丘脑多种功能中的重要作用，这是本文的重点。
All of the canonical transient receptor potential channels (TRPC) with the exception of TRPC 2 are expressed in hypothalamic neurons and are involved in multiple homeostatic functions. Although the metabotropic glutamate receptors have been shown to be coupled to TRPC channel activation in cortical and sub-cortical brain regions, in the hypothalamus multiple amine and peptidergic G protein-coupled receptors (GPCRs) and growth factor/cytokine receptors are linked to activation of TRPC channels that are vital for reproduction, temperature regulation, arousal and energy homeostasis. In addition to the neurotransmitters, circulating hormones like insulin and leptin through their cognate receptors activate TRPC channels in POMC neurons. Many of the post-synaptic effects of the neurotransmitters and hormones are regulated in different physiological states by expression of TRPC channels in the post-synaptic neurons. Therefore, TRPC channels are key targets not only for neurotransmitters but circulating hormones in their vital role to control multiple hypothalamic functions, which is the focus of this review.
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影响因子：
29
作者：
Al-Qassab H;Smith MA;Irvine EE;Guillermet-Guibert J;Claret M;Choudhury AI;Selman C;Piipari K;Clements M;Lingard S;Chandarana K;Bell JD;Barsh GS;Smith AJ;Batterham RL;Ashford ML;Vanhaesebroeck B;Withers DJ
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DOI：
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发表时间：
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
De Lecea, Luis
DOI：
10.1073/pnas.1713897114
发表时间：
2017-11-21
影响因子：
11.1
作者：
Clarkson, Jenny;Han, Su Young;Herbison, Allan E.
通讯作者：
Herbison, Allan E.