Modelling morphogenesis: From single cells to crawling slugs
Modelling morphogenesis: From single cells to crawling slugs
复制标题
DOI：
10.1006/jtbi.1996.0237
复制
发表时间：
1997-02-07
影响因子：
2
通讯作者：
Hogeweg, P
中科院分区：
文献类型：
--
作者：
Savill, NJ;Hogeweg, P
我们提出了一个三维混合元胞自动机。(CA)/偏微分方程（PDE）模型，允许在简单的细胞系统中的形态发生的研究。我们将该模型应用于细胞黏菌盘基网柄菌“从单细胞到爬行鼻涕虫”。使用简单的局部相互作用，我们可以实现基本的形态发生只有三个过程：生产和趋化cAMP和细胞粘附。这些过程的相互作用导致变形虫在空间上自组织，从而导致流和丘形成，细胞分选和蛞蝓迁移的复杂行为，而在整个形态发生过程中没有任何参数的变化。(C)出版社：Academic Press Limited。
We present a three-dimensional hybrid cellular automata. (CA)/partial differential equation (PDE) model that allows for the study of morphogenesis in simple cellular systems. We apply the model to the cellular slime mold Dictyostelium discoideum ''from single cells to crawling slug''. Using simple local interactions we can achieve the basic morphogenesis with only three processes: production of and chemotaxis to cAMP and cellular adhesion. The interplay of these processes causes the amoebae to spatially self-organize leading to the complex behaviour of stream and mound formation, cell sorting and slug migration all without any change of parameters during the complete morphogenetic process. (C) 1997 Academic Press Limited.