Intrinsic fluctuations within cortical systems account for intertrial variability in human Behavior
Intrinsic fluctuations within cortical systems account for intertrial variability in human Behavior
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DOI：
10.1016/j.neuron.2007.08.023
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发表时间：
2007-10-04
期刊：
影响因子：
16.2
通讯作者：
Raichle, Marcus E.
中科院分区：
文献类型：
--
作者：
Fox, Michael D.;Snyder, Abraham Z.;Raichle, Marcus E.
休息时的大脑并不是沉默的，即使在没有任务或刺激的情况下，它也会表现出有组织的神经元活动波动。这种内在的大脑活动在任务执行过程中持续存在，并有助于诱发大脑反应的变化。我们不知道的是，这种内在的活动是否也会导致行为的变化。在目前的功能磁共振成像研究中，我们确定了人类大脑活动之间的关系，在左somatornotor皮层和自发的试验到试验的按钮按下力的变化。然后，我们证明，74%的这种大脑行为的关系是归因于持续的波动，类似于在休息固定观察到的内在活动。除了建立内在大脑活动的功能和行为意义外，这些结果还为人类行为变异性的起源提供了新的见解。
The resting brain is not silent, but exhibits organized fluctuations in neuronal activity even in the absence of tasks or stimuli. This intrinsic brain activity persists during task performance and contributes to variability in evoked brain responses. What is unknown is if this intrinsic activity also contributes to variability in behavior. In the current fMRI study, we identify a relationship between human brain activity in the left somatornotor cortex and spontaneous trial-to-trial variability in button press force. We then demonstrate that 74% of this brain-behavior relationship is attributable to ongoing fluctuations in intrinsic activity similar to those observed during resting fixation. In addition to establishing a functional and behavioral significance of intrinsic brain activity, these results lend new insight into the origins of variability in human behavior.