Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient.
Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient.
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DOI：
10.1007/s10157-007-0463-x
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发表时间：
2007-06-01
影响因子：
2.3
通讯作者：
Matsuo, Seiichi
中科院分区：
文献类型：
--
作者：
Imai, Enyu;Horio, Masaru;Matsuo, Seiichi
背景：在过去的三十年里，日本终末期肾病(ESRD)患者的数量持续增加。2005年，36,063名患者进入了新的透析计划，他们的平均年龄为66岁。如此大量的终末期肾病患者可能只是越来越多的慢性肾脏疾病(CKD)患者的冰山一角。方法：527,594人(男性，211,034人；女性，316,560人)的数据来自日本的7个县：北海道、福岛、茨城、东京、大阪、福冈和冲绳县。结果：按20~29岁、30~39岁、40~49岁、50~59岁、60~69岁、70~79岁和80~89岁年龄组分层，肾小球滤过率(GFR)分别为1.4%、3.6%、10.8%、15.9%、31.8%、44.0%和59.1%。预计2004年日本总人口为1.032亿人中，将有1910万名CKD患者进入第三阶段。在日本普通成人人群中，有200,000名患者预测CKD分期为4+5。随着估计的肾小球滤过率(EGFR)降低，高血压、糖尿病和蛋白尿的并存增加。在高血压和糖尿病人群中并发CKD的患病率显著高于总体研究人群，当CKD被定义为EGFR低于40ml/min/1.73m(2)而不是低于60ml/min/1.73m(2)时。结论：大约20%的日本成年人口(即约1900万人)被预测为3-5期CKD，其定义为GFR<60ml/min/1.73m(2)。
BACKGROUND: The number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36,063 patients whose average age was 66 years entered a new dialysis program. This large number of ESRD patients could be just the tip of the iceberg of an increasing number of patients with chronic kidney disease (CKD). However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population.METHODS: Data for 527,594 (male, 211,034; female, 316,560) participants were obtained from the general adult population aged over 20 years who received annual health check programs in 2000-2004, from seven different prefectures in Japan: Hokkaido, Fukushima, Ibaraki, Tokyo, Osaka, Fukuoka, and Okinawa prefectures. The glomerular filtration rate (GFR) for each participant was estimated from the serum creatinine values, using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation modified by the Japanese coefficient.RESULTS: The prevalences of CKD stage 3 in the study population, stratified by age groups of 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-89 years, were 1.4%, 3.6%, 10.8%, 15.9%, 31.8%, 44.0%, and 59.1%, respectively, predicting 19.1 million patients with stage 3 CKD in the Japanese general adult population of 103.2 million in 2004. CKD stage 4 + 5 was predicted in 200,000 patients in the Japanese general adult population. Comorbidity of hypertension, diabetes, and proteinuria increased as the estimated GFR (eGFR) decreased. The prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall when CKD was defined as being present with an eGFR of less than 40 ml/min per 1.73 m(2) instead of less than 60 ml/min per 1.73 m(2).CONCLUSIONS: About 20% of the Japanese adult population (i.e., approximately 19 million people) are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m(2).