The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment
The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment
复制标题
派尔氏淋巴集结中 B 淋巴细胞倾向于表达抗体的 IgA 同种型，这可能是由于其微环境的内在特性
作者：
J. Cebra;A. Logan;P. Weinstein
结论PP和LN在两种类型的急性、原发GC反应中迅速转换为不同的非IgM/IgD同种型表达，提示其微环境的内在差异是同种型偏好的基础。
ConclusionThe prompt switching to the expression of different non-IgM/IgD isotypes in PP and LN during acute, de novo GC reactions at the two types of sites suggests intrinsic differences in their microenvironments as the basis for isotype preference.