CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors
CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors
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DOI：
10.1016/s0006-3223(95)00675-3
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发表时间：
1996-12-01
影响因子：
10.6
通讯作者：
Linnoila, M
中科院分区：
文献类型：
--
作者：
Higley, JD;Mehlman, PT;Linnoila, M
我们通过测量自由放养的青春期雄性非人灵长类动物的每种生化和行为，研究了睾酮和5-羟色胺在各种形式的攻击性和暴力行为中的潜在作用。我们的研究结果表明：（1）脑脊液游离睾酮浓度与总体攻击性呈正相关，但与冲动性指标无关。(2)CSF中5-HIAA浓度与冲动行为和严重、无限制的攻击行为呈负相关，但与总体攻击行为率无关。高冲动行为率与严重、无限制的攻击行为呈正相关，但与总体攻击行为率无关。(3)维度分析显示，虽然低CSF 5-HIAA受试者表现出高攻击率，但高CSF睾酮进一步增加了低CSF 5-HIAA受试者的攻击率和强度。我们的结论是，高CSF游离睾酮浓度与竞争性攻击，而低CSF 5-HIAA浓度与严重的侵略，这是由于受损的冲动控制和毅力。(C)1996年生物精神病学学会
We studied the potential roles of testosterone and serotonin in various forms of aggressive and violent behaviors by measuring each biochemical and behavior in free-ranging adolescent male nonhuman primates. Our results showed that (1) CSF free testosterone concentrations were positively correlated with overall aggressiveness, but not with measures of impulsivity. (2) CSF 5-HIAA concentrations were negatively correlated with impulsive behavior, and severe, unrestrained aggression, but not with overall rates of aggression, High rates of impulsive behavior were positively correlated with severe, unrestrained aggression, but not overall rates of aggression. (3) Dimensional analyses showed that while subjects with low CSF 5-HIAA exhibited high rates of aggression, high CSF testosterone further augmented rates and intensity of aggression in subjects with low CSF 5-HIAA. We conclude that high CSF free testosterone concentrations are associated with competitive aggression, while low CSF 5-HIAA concentrations are associated with severe aggression which results from impaired impulse control, and perseverance. (C) 1996 Society of Biological Psychiatry