Functional connectivity density mapping
Functional connectivity density mapping
复制标题
DOI：
10.1073/pnas.1001414107
复制
发表时间：
2010-05-25
影响因子：
11.1
通讯作者：
Volkow, Nora D.
中科院分区：
文献类型：
--
作者：
Tomasi, Dardo;Volkow, Nora D.
具有高能效中枢的大脑网络可能支持人类的高认知能力，更好地了解它们的组织结构可能不仅对研究大脑发育和可塑性，而且对研究神经精神障碍也有意义。然而，由于综合分析方法的高计算要求，人脑中枢的分布在很大程度上是未知的。在这里，我们提出了一种更快10(3)倍的方法来绘制人脑局部功能连接密度(LFCD)的分布。该方法的稳健性在979名受试者中进行了测试，这些受试者来自于在静息条件下收集的大量MRI时间序列。在不同的研究地点，位于扣带后/楔前腹侧的区域(BA 23/31)是IFCD最高的区域，这表明这是大脑中最显著的功能中枢。此外，位于顶叶下部皮质(BA 18)和楔叶(BA 18)的LFCD较高。这一模式在不同受试者中的可变性是
Brain networks with energy-efficient hubs might support the high cognitive performance of humans and a better understanding of their organization is likely of relevance for studying not only brain development and plasticity but also neuropsychiatric disorders. However, the distribution of hubs in the human brain is largely unknown due to the high computational demands of comprehensive analytical methods. Here we propose a 10(3) times faster method to map the distribution of the local functional connectivity density (lFCD) in the human brain. The robustness of this method was tested in 979 subjects from a large repository of MRI time series collected in resting conditions. Consistently across research sites, a region located in the posterior cingulate/ventral precuneus (BA 23/31) was the area with the highest IFCD, which suggest that this is the most prominent functional hub in the brain. In addition, regions located in the inferior parietal cortex (BA 18) and cuneus (BA 18) had high lFCD. The variability of this pattern across subjects was