Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26
Growth inhibition by metabolites of γ-hexachlorocyclohexane in Sphingobium japonicum UT26
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DOI：
10.1271/bbb.70.1029
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发表时间：
2006-04-01
影响因子：
1.6
通讯作者：
Nagata, Y
中科院分区：
文献类型：
--
作者：
Endo, R;Ohtsubo, Y;Nagata, Y
对六氯环己烷降解菌Sphingobium Japan onicum(原少见鞘氨醇单胞菌)UT26在富营养液中的生长有抑制作用。在缺乏对伽马-六氯环己烷降解的第一步或第二步酶活性的突变体中没有观察到这种生长抑制，这表明伽马-六氯环己烷的代谢产物对UT26是有毒的。γ-六氯环己烷的两种代谢物2，5-二氯苯酚(2，5-DCP)和2，5-二氯对苯二酚(2，5-DCHQ)对UT26和其他鞘氨醇单胞菌有直接毒性作用。由于在六氯环己烷降解过程中只积累了2，5-二氯环己烷，2，5-二氯环己烷被认为是抑制生长的主要化合物。
The growth of a gamma-hexachlorocyclohexane (gamma-HCH)-degrading bacterium Sphingobium japonicum (formerly Sphingomonas paucimobilis) UT26 in rich medium was inhibited by gamma-HCH. This growth inhibition was not observed in a mutant that lacked the initial or second step enzymatic activity for gamma-HCH degradation, suggesting that metabolites of gamma-HCH are toxic to UT26. Two metabolites of gamma-HCH, 2,5-dichlorophenol (2,5-DCP) and 2,5-dichlorohydroquinone (2,5-DCHQ), showed a direct toxic effect on UT26 and other sphingomonad strains. Because only 2,5-DCP accumulated during gamma-HCH degradation, 2,5-DCP is thought to be a main compound for growth inhibition.