MEF2C, A MADS MEF2-FAMILY TRANSCRIPTION FACTOR EXPRESSED IN A LAMINAR DISTRIBUTION IN CEREBRAL-CORTEX
MEF2C, A MADS MEF2-FAMILY TRANSCRIPTION FACTOR EXPRESSED IN A LAMINAR DISTRIBUTION IN CEREBRAL-CORTEX
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DOI：
10.1073/pnas.90.4.1546
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发表时间：
1993-02-15
影响因子：
11.1
通讯作者：
LIPTON, SA
中科院分区：
文献类型：
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作者：
LEIFER, D;KRAINC, D;LIPTON, SA
我们克隆了编码人类转录因子的cDNA，该转录因子属于MADS（MCM 1-无性生殖缺陷-血清反应因子）基因家族的MEF 2（肌细胞特异性增强子结合因子2）亚家族。我们将该因子命名为MEF 2C，其特异性结合MEF 2元件并通过该元件激活转录。该因子的特异性同种型仅在脑中发现，并由大脑皮层中的神经元强烈表达。原位杂交表明，该因子优先表达在某些神经元层的皮质和表达下降，在出生后的发展。在大脑中表达的不寻常的模式表明，这种转录因子可能是重要的皮质结构的发展。
We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding factor 2) subfamily of the MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we have named MEF2C, binds specifically to the MEF2 element and activates transcription via this element. Specific isoforms of this factor are found exclusively in brain and are robustly expressed by neurons in cerebral cortex. In situ hybridization indicates that the factor is expressed preferentially in certain neuronal layers of cortex and that expression declines during postnatal development. The unusual pattern of expression in brain suggests that this transcription factor may be important in the development of cortical architecture.