Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.
Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.
复制标题
膜和弯曲刚度对主动脉瓣动力学的影响：识别较薄生物组织中小叶扑动的机制。
DOI：
10.1016/j.finmec.2021.100053
复制
发表时间：
2022
影响因子：
--
通讯作者：
Hsu,Ming-Chen
中科院分区：
文献类型：
--
作者：
Johnson,EmilyL;Rajanna,ManojR;Yang,Cheng-Hau;Hsu,Ming-Chen
导致主动脉瓣恶化的瓣膜病变是老年人群中心脏病的常见原因。尽管有许多可用技术可以通过用生物假体植入物替换患病瓣膜来治疗瓣膜疾病并复制正常主动脉功能，但其中许多设备在长期耐用性方面面临挑战。一种可能加剧瓣膜退化并在主动脉中引起不良血流动力学效应的现象是小叶扑动，其特征在于生物组织中的振荡运动。虽然在较薄的生物瓣膜中观察到了这种行为，但导致瓣叶扑动的具体潜在机制此前尚未确定。这项工作提出了一种计算方法来分离在心动周期期间在较薄的生物组织中引起小叶扑动的基本力学。这项工作中的模拟将弯曲刚度的降低确定为导致较薄生物组织中小叶颤动增加的主要因素，而较薄组织的膜刚度和质量降低不会直接引起这些瓣膜的颤动。这项研究的结果加深了对导致扑动的机械组织特性的理解，并为生物假体组织设计的可能发展提供了重要见解，以解决和减少扑动的发生率。
Valvular pathologies that induce deterioration in the aortic valve are a common cause of heart disease among aging populations. Although there are numerous available technologies to treat valvular conditions and replicate normal aortic function by replacing the diseased valve with a bioprosthetic implant, many of these devices face challenges in terms of long-term durability. One such phenomenon that may exacerbate valve deterioration and induce undesirable hemodynamic effects in the aorta is leaflet flutter, which is characterized by oscillatory motion in the biological tissues. While this behavior has been observed for thinner bioprosthetic valves, the specific underlying mechanics that lead to leaflet flutter have not previously been identified. This work proposes a computational approach to isolate the fundamental mechanics that induce leaflet flutter in thinner biological tissues during the cardiac cycle. The simulations in this work identify reduced flexural stiffness as the primary factor that contributes to increased leaflet flutter in thinner biological tissues, while decreased membrane stiffness and mass of the thinner tissues do not directly induce flutter in these valves. The results of this study provide an improved understanding of the mechanical tissue properties that contribute to flutter and offer significant insights into possible developments in the design of bioprosthetic tissues to account for and reduce the incidence of flutter.