Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer
Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer
复制标题
DOI：
10.1016/s0142-9612(03)00162-5
复制
发表时间：
2003-08-01
期刊：
影响因子：
14
通讯作者：
Ko, JS
中科院分区：
文献类型：
--
作者：
Kim, HW;Lee, SY;Ko, JS
采用聚合物海绵复制技术制备高孔隙度氧化锆（ZrO 2）骨支架，并在其表面涂覆羟基磷灰石（HA）。为了防止ZrO 2和HA之间的化学反应，引入了中间氟磷灰石（FA）层。多孔ZrO_2的强度比纯HA高7倍，表明多孔ZrO_2支架作为承重部件应用的可行性。涂覆的HA/FA层，具有约30 μ m的厚度，牢固地粘附到ZrO 2主体，具有22 MPa的结合强度。成骨细胞样细胞在多孔支架的涂层上附着并良好地扩散。HA/FA包被的ZrO 2上增殖的细胞的碱性磷酸酶活性与纯HA上的碱性磷酸酶活性相当，并且高于纯ZrO 2上的碱性磷酸酶活性。(C)2003爱思唯尔科技有限公司版权所有。
Highly porous zirconia (ZrO2) bone scaffolds, fabricated by a replication technique using polymeric sponge, were coated with hydroxyapatite (HA). To prevent the chemical reactions between ZrO2 and HA, an intermediate fluorapatite (FA) layer was introduced. The strength of the Porous ZrO2 Was higher than that of pure HA by a factor of 7, suggesting the feasibility of ZrO2, porous scaffolds as load-bearing part applications. The coated HA/FA layer, with a thickness of about 30 mum, was firmly adhered to the ZrO2 body, with a bonding strength of 22MPa. The osteoblast-like cells were attached and spread well on the coating layer throughout the porous scaffolds. The alkaline phosphatase activity of the proliferated cells on the HA/FA coated ZrO2 was comparable to that on pure HA and higher than that on pure ZrO2. (C) 2003 Elsevier Science Ltd. All rights reserved.