Insular cortex lesions and taste aversion learning: effects of conditioning method and timing of lesion
Insular cortex lesions and taste aversion learning: effects of conditioning method and timing of lesion
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DOI：
10.1016/s0006-8993(99)01745-x
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发表时间：
1999-08-28
期刊：
影响因子：
2.9
通讯作者：
Bernstein, IL
中科院分区：
文献类型：
--
作者：
Cubero, I;Thiele, TE;Bernstein, IL
岛叶皮层在条件性味觉厌恶的获得和表达中的特定作用使用两种不同的条件化方法进行评估，这两种方法改变了味觉传递的模式。还评估了岛叶皮质在孤束核中诱导c-Fos免疫反应性的参与，孤束核是条件性味觉厌恶的行为表达的细胞相关物。岛叶皮层的电解质病变阻断了条件性味觉厌恶的行为表达，这是显而易见的，不仅当病变被放置在空调前，但也当他们被空调后，但测试之前。与对行为的影响相反，病变并没有完全阻断c-Fos免疫反应性，伴随着再次暴露于厌恶的味道。此外，在口内采集程序下训练的动物和瓶条件反射训练的动物中，均观察到皮质病变对厌恶条件反射行为证据的阻断。这与以前的工作与杏仁核病变，表明杏仁核是绝对必要的味觉厌恶条件与口内的方法，但不为那些条件使用瓶介绍的味道。总的来说，这些研究结果意味着参与味觉厌恶学习的神经回路的细节，包括其解剖分布，复杂性和冗余程度，随所采用的条件反射方法的类型而变化。(C)1999 Elsevier Science B. V.保留所有权利。
The specific role of insular cortex in acquisition and expression of a conditioned taste aversion was assessed using two different conditioning methods, which vary mode of taste delivery. Involvement of insular cortex in the induction of c-Fos-immunoreactivity in the nucleus of the solitary tract, a cellular correlate of the behavioral expression of a conditioned taste aversion, was also assessed. Electrolytic lesions of insular cortex blocked behavioral expression of a conditioned taste aversion and this was evident not only when lesions were placed prior to conditioning, but also when they were made after conditioning but before testing. In contrast to the effects on behavior, lesions did not completely block the c-Fos-immunoreactivity which accompanies re-exposure to the aversive taste. In addition, the blocking of behavioral evidence of aversion conditioning by cortical lesions was seen both in animals trained under an intraoral acquisition procedure and those trained with bottle-conditioning. This contrasts with previous work with amygdala lesions which showed that amygdala was absolutely necessary for taste aversions conditioned with the intraoral method but not for those conditioned using bottle presentation of the taste. Overall, these findings imply that the details of the neural circuitry involved in taste aversion learning, including its anatomical distribution, complexity and degree of redundancy, vary with the type of conditioning method employed. (C) 1999 Elsevier Science B.V. All rights reserved.