PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN-VITRO IS REDUCED IN WHOLE-BLOOD OF SEVERELY MALNOURISHED CHILDREN
PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN-VITRO IS REDUCED IN WHOLE-BLOOD OF SEVERELY MALNOURISHED CHILDREN
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DOI：
10.1042/cs0860347
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发表时间：
1994-03-01
期刊：
影响因子：
6
通讯作者：
GRIFFIN, GE
中科院分区：
文献类型：
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作者：
DOHERTY, JF;GOLDEN, MHN;GRIFFIN, GE
1.对16名营养不良儿童在营养恢复前后细胞因子的体外产生进行了评估.检测脂多糖刺激后全血中肿瘤坏死因子-α和白细胞介素-6的含量.与营养康复后的儿童相比，营养不良儿童在孵育24 h后两种细胞因子的总量显著减少.严重营养不良儿童体外细胞因子产生受损。
1. Cytokine production in vitro was assessed in 16 malnourished children, before and after nutritional recovery.2. Tumour necrosis factor-alpha and interleukin-6 were measured in whole blood after lipopolysaccharide stimulation.3. The total amount of both cytokines was significantly less after 24 h incubation among malnourished children when compared with the same children after nutritional rehabilitation.4. Cytokine production in vitro is impaired in severely malnourished children.