Monitoring transcranial direct current stimulation induced changes in cortical excitability during the serial reaction time task
Monitoring transcranial direct current stimulation induced changes in cortical excitability during the serial reaction time task
复制标题
DOI：
10.1016/j.neulet.2016.01.039
复制
发表时间：
2016-03-11
影响因子：
2.5
通讯作者：
Paulus, Walter
中科院分区：
文献类型：
--
作者：
Ambrus, Geza Gergely;Chaieb, Leila;Paulus, Walter
利用单脉冲经颅磁刺激（TMS）测量运动诱发电位（MEP）幅度是观察运动皮层兴奋性变化的常用方法。皮质兴奋性的水平已被证明在运动学习过程中会发生变化。相反，运动学习可以通过使用阳极经颅直流电刺激（tDCS）来改善。在本研究中，我们的目的是监测皮层兴奋性的变化过程中的内隐运动学习范式，一个版本的串行反应时间任务（SRTT）。第一背侧骨间肌（FDI）和前臂屈肌（FLEX）的反应被记录之前，期间和之后的性能SRTT。在SRTT.Negative相关性的在线测量相结合的阳极，阴极或假tDCS的持续时间在阴极条件下的学习块（较高的平均MEP幅度与较低的RTs相关），但在阳极和假条件下没有显着差异，在线FDI MEP的幅度和SRTT反应时间（RTs）之间的负相关性。tDCS对SRTT性能没有影响，这与基于先前研究的预测一致。离线前后SRTT MEP波幅在阳极刺激后呈上升趋势，阴极刺激后呈下降趋势，但变化不明显，tDCS期间不同干预措施的组合可能会导致刺激效果的降低，在未来的研究中需要进一步关注。(C)2016爱思唯尔爱尔兰有限公司版权所有。
The measurement of the motor evoked potential (MEP) amplitudes using single pulse transcranial magnetic stimulation (TMS) is a common method to observe changes in motor cortical excitability. The level of cortical excitability has been shown to change during motor learning. Conversely, motor learning can be improved by using anodal transcranial direct current stimulation (tDCS). In the present study, we aimed to monitor cortical excitability changes during an implicit motor learning paradigm, a version of the serial reaction time task (SRTT). Responses from the first dorsal interosseous (FDI) and forearm flexor (FLEX) muscles were recorded before, during and after the performance of the SRTT. Online measurements were combined with anodal, cathodal or sham tDCS for the duration of the SRTT.Negative correlations between the amplitude of online FDI MEPs and SRTT reaction times (RTs) were observed across the learning blocks in the cathodal condition (higher average MEP amplitudes associated with lower RTs) but no significant differences in the anodal and sham conditions. tDCS did not have an impact on SRTT performance, as would be predicted based on previous studies. The offline before after SRTT MEP amplitudes showed an increase after anodal and a tendency to decrease after cathodal stimulation, but these changes were not significant.The combination of different interventions during tDCS might result in reduced efficacy of the stimulation that in future studies need further attention. (C) 2016 Elsevier Ireland Ltd. All rights reserved.