Molecular genetics of attention-deficit/hyperactivity disorder
Molecular genetics of attention-deficit/hyperactivity disorder
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DOI：
10.1016/j.biopsych.2004.11.024
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发表时间：
2005-06-01
影响因子：
10.6
通讯作者：
Sklar, P
中科院分区：
文献类型：
--
作者：
Faraone, SV;Perlis, RH;Sklar, P
行为遗传学和分子遗传学研究的结果表明，遗传和非遗传因素都有助于注意力缺陷多动障碍（ADHD）的发展。我们回顾了这方面的文献，特别强调石油分子遗传学研究。家庭、双胞胎和收养研究提供了令人信服的证据表明基因在调节多动症易感性方面起着重要作用。这一事实在现存的20项双胞胎研究中最为明显，这些研究估计ADHD的遗传率为76。分子遗传学研究表明，ADHD的遗传结构是复杂的。迄今为止进行的几次全基因组扫描并不具有决定性。与此相反，ADHD的许多候选基因研究已经产生了大量证据，表明该疾病的病因涉及几个基因。对于在三个或更多病例对照或基于家族的研究中研究了相同变体的八个基因，七个基因显示出统计学显著的关联证据，基于跨研究的汇总比值比。
Results of behavioral genetic and molecular genetic studies have converged to suggest that both genetic and nongenetic factors contribute to the development of attention-deficit/hyperactivity disorder (ADHD). We review this literature, with a particular emphasis oil molecular genetic studies. Family, twin, and adoption studies provide compelling evidence That genes play a strong role ill mediating susceptibility to ADHD. This fact is most clearly seen in the 20 extant twin studies, which estimate the heritability of ADHD to be 76. Molecular genetic studies suggest that the genetic architecture of ADHD is complex. The few genome-wide scans conducted thus far are not conclusive. In contrast, the many candidate gene studies of ADHD have produced substantial evidence implicating several genes in the etiology of the disorder. For the eight genes for which The same variant has been studied in three or more case-control or family-based studies, seven show statistically significantly evidence of association, with ADHD on the basis of the pooled odds ratio across studies.