Impulsivity and phase of illness in bipolar disorder
Impulsivity and phase of illness in bipolar disorder
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双相情感障碍的冲动和疾病阶段
DOI：
10.1016/s0165-0327(02)00328-2
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发表时间：
2003-01-01
影响因子：
6.6
通讯作者：
Moeller, FG
中科院分区：
文献类型：
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作者：
Swann, AC;Pazzaglia, P;Moeller, FG
背景：冲动性在双相情感障碍中很突出，但很少有定量信息将其与疾病阶段联系起来。研究方法：我们测量了至少6个月未达到发作标准的双相情感障碍患者、躁狂患者和健康对照组的冲动性。使用Barratt冲动量表（BIS）和计算机化的即时记忆-远程记忆任务（IMT-DMT）的表现来测量冲动性，基于连续表现测试，该测试已被证明可以反映其他人群的冲动性风险。结果：正常心境和躁狂双相情感障碍患者的BIS评分相同，与对照组相比显著升高。委员会错误（冲动反应）的IMT-DMT升高躁狂症的主题，但在正常的主题控制是相同的。冲动性的测量似乎与抑郁症状无关。局限性：受试者数量太少，无法详细研究合并症的作用;受试者正在接受药物治疗。结论：双相情感障碍的冲动性具有状态和特质相关的方面。(C)出版社：Elsevier Science B. V.
Background: Impulsivity is prominent in bipolar disorder, but there is little quantitative information relating it to phase of illness. Methods: We measured impulsivity in patients with bipolar disorder who had not met episode criteria for at least 6 months, patients who were manic, and healthy control subjects. Impulsivity was measured using the Barratt Impulsiveness Scale (BIS) and performance on the computerized Immediate Memory-Remote Memory Task (IMT-DMT), based on the Continuous Performance Test, which has been shown to reflect risk of impulsivity in other populations. Results: BIS scores in euthymic and manic bipolar subjects were identical, and were significantly elevated compared to controls. Commission errors (impulsive responses) on the IMT-DMT were elevated in manic subjects but were identical to controls in euthymic subjects. Measures of impulsivity did not appear related to depressive symptoms. Limitations: The number of subjects was too small for detailed investigation of the role of comorbidities; subjects were receiving pharmacological treatments. Conclusions: Impulsivity has state- and trait-related aspects in bipolar disorder. (C) 2002 Published by Elsevier Science B.V.