Acupuncture versus topiramate in chronic migraine prophylaxis: A randomized clinical trial
Acupuncture versus topiramate in chronic migraine prophylaxis: A randomized clinical trial
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DOI：
10.1177/0333102411420585
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发表时间：
2011-10
期刊：
影响因子：
4.9
通讯作者：
C-P Yang;M.-H. Chang;Peng Liu;T-C Li;C. Hsieh;K. Hwang;H. Chang
中科院分区：
文献类型：
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作者：
C-P Yang;M.-H. Chang;Peng Liu;T-C Li;C. Hsieh;K. Hwang;H. Chang
背景资料：本研究的目的是探讨针灸与托吡酯预防慢性偏头痛（CM）的疗效和耐受性。研究方法：共有66名连续和前瞻性CM患者被随机分为两个治疗组：1）针灸组：在12周内进行24次针灸治疗（n = 33）; 2）托吡酯组：4周滴定，起始剂量为25 mg/天，每周增加25 mg/天至最大剂量100 mg/天，随后为8周维持期（n = 33）。结果如下：中度/重度头痛的平均月天数显著减少主要终点时间针刺组为（20.2 ± 1.5）d，托吡酯组为（19.8 ± 1.7）d，托吡酯组为（12.0 ± 4.1）d（p <0.01）对于所有次要疗效变量，也观察到有利于针灸的显著差异。当我们关注那些过度使用急性药物的患者时，这些显著差异仍然存在。针刺组不良事件发生率为6%，托吡酯组不良事件发生率为66%。结论：我们建议，针灸可以被认为是一种治疗选择CM患者愿意接受这种预防性治疗，即使是那些过度使用药物的患者。
Background: The aim of this study was to investigate the efficacy and tolerability of acupuncture compared with topiramate treatment in chronic migraine (CM) prophylaxis. Methods: A total of 66 consecutive and prospective CM patients were randomly divided into two treatment arms: 1) acupuncture group: acupuncture administered in 24 sessions over 12 weeks (n = 33); and 2) topiramate group: a 4-week titration, initiated at 25 mg/day and increased by 25 mg/day weekly to a maximum of 100 mg/day followed by an 8-week maintenance period (n = 33). Results: A significantly larger decrease in the mean monthly number of moderate/severe headache days (primary end point) from 20.2 ± 1.5 days to 9.8 ± 2.8 days was observed in the acupuncture group compared with 19.8 ± 1.7 days to 12.0 ± 4.1 days in the topiramate group (p < .01) Significant differences favoring acupuncture were also observed for all secondary efficacy variables. These significant differences still existed when we focused on those patients who were overusing acute medication. Adverse events occurred in 6% of acupuncture group and 66% of topiramate group. Conclusion: We suggest that acupuncture could be considered a treatment option for CM patients willing to undergo this prophylactic treatment, even for those patients with medication overuse.