Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
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DOI：
10.1002/path.2514
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发表时间：
2009-05-01
影响因子：
7.3
通讯作者：
Delattre, Olivier
中科院分区：
文献类型：
--
作者：
Fattet, Sarah;Haberler, Christine;Delattre, Olivier
髓母细胞瘤是最常见的儿童恶性脑肿瘤。Wnt/β-连环蛋白通路的激活发生在10-15%的髓母细胞瘤中，最近被描述为有利患者结局的标志物。我们报告了一系列的72例儿童髓母细胞瘤的β-连环蛋白表达，CTNNB 1突变和比较基因组杂交评价。基因表达谱也可在一个子集的40例。β-连环蛋白的免疫染色显示6例肿瘤细胞广泛核染色（>50%的肿瘤细胞），
Medulloblastoma is the most frequent malignant paediatric brain tumour. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for favourable patient outcome. We report a series of 72 paediatric medulloblastomas evaluated for beta-catenin protein expression, CTNNB1 mutations, and comparative genomic hybridization. Gene expression profiles were also available in a subset of 40 cases. Immunostaining of beta-catenin showed extensive nuclear staining (>50% of the tumour cells) in six cases and focal nuclear staining (