Restoring continuous finger function with temporarily paralyzed nonhuman primates using brain-machine interfaces.
Restoring continuous finger function with temporarily paralyzed nonhuman primates using brain-machine interfaces.
复制标题
使用脑机接口恢复暂时瘫痪的非人类灵长类动物的连续手指功能。
DOI：
10.1088/1741-2552/accf36
复制
发表时间：
2023
影响因子：
4
通讯作者：
Patil,ParagG
中科院分区：
文献类型：
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作者：
Nason-Tomaszewski,SamuelR;Mender,MatthewJ;Kennedy,Eric;Lambrecht,JorisM;Kilgore,KevinL;Chiravuri,Srinivas;GaneshKumar,Nishant;Kung,TheodoreA;Willsey,MatthewS;Chestek,CynthiaA;Patil,ParagG
脑-机接口（BMIs）在从非人灵长类动物和四肢瘫痪患者的思想中提取上肢运动意图方面表现出了希望。恢复使用者自己的手和手臂功能的尝试已经采用了功能性电刺激（FES），但是大多数工作已经恢复了离散的抓握。人们对FES控制连续手指运动的能力知之甚少。在这里，我们使用一个低功率的脑控制功能性电刺激（BCFES）系统，以恢复手指位置的连续意志控制猴子暂时瘫痪hand.ApproachWe提供了一个神经阻滞的正中，桡，尺神经近手肘的肘部，以模拟手指麻痹，然后使用一个闭环BMI预测手指运动的猴子试图在两个任务。BCFES任务是一维的，其中所有手指一起移动，我们使用BMI的预测来控制猴子手指肌肉的FES。虚拟双指任务是二维的，其中食指同时独立于中指，无名指和小指移动，我们使用BMI的预测来控制虚拟手指的运动，没有FES。猴子将成功率提高到83%（1.5 s中位采集时间），从8.8%（9.5 s中位采集时间，等于试验超时），当试图使用他暂时瘫痪的手。在一只没有FES的猴子中，我们发现BMI表现结果表明，BCFES可以利用现有的低功耗技术和脑功能，在暂时性瘫痪期间恢复手指的连续功能。控制可能不是BCFES神经假体的限制因素。
ObjectiveBrain–machine interfaces (BMIs) have shown promise in extracting upper extremity movement intention from the thoughts of nonhuman primates and people with tetraplegia. Attempts to restore a user's own hand and arm function have employed functional electrical stimulation (FES), but most work has restored discrete grasps. Little is known about how well FES can control continuous finger movements. Here, we use a low-power brain-controlled functional electrical stimulation (BCFES) system to restore continuous volitional control of finger positions to a monkey with a temporarily paralyzed hand.ApproachWe delivered a nerve block to the median, radial, and ulnar nerves just proximal to the elbow to simulate finger paralysis, then used a closed-loop BMI to predict finger movements the monkey was attempting to make in two tasks. The BCFES task was one-dimensional in which all fingers moved together, and we used the BMI's predictions to control FES of the monkey's finger muscles. The virtual two-finger task was two-dimensional in which the index finger moved simultaneously and independently from the middle, ring, and small fingers, and we used the BMI's predictions to control movements of virtual fingers, with no FES.Main resultsIn the BCFES task, the monkey improved his success rate to 83%(1.5 s median acquisition time) when using the BCFES system during temporary paralysis from 8.8%(9.5 s median acquisition time, equal to the trial timeout) when attempting to use his temporarily paralyzed hand. In one monkey performing the virtual two-finger task with no FES, we found BMI performance (task success rate and completion time) could be completely recovered following temporary paralysis by executing recalibrated feedback-intention training one time.SignificanceThese results suggest that BCFES can restore continuous finger function during temporary paralysis using existing low-power technologies and brain-control may not be the limiting factor in a BCFES neuroprosthesis.