Relationship between multiple sclerosis intention tremor severity and lesion load in the brainstem
Relationship between multiple sclerosis intention tremor severity and lesion load in the brainstem
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DOI：
10.1097/01.wnr.0000176521.26971.58
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发表时间：
2005-08-22
期刊：
影响因子：
1.7
通讯作者：
Liu, XG
中科院分区：
文献类型：
--
作者：
Feys, P;Maes, F;Liu, XG
多发性硬化症引起的意向性震颤在临床上与小脑性震颤相似。本研究调查了 14 名多发性硬化症患者的意向性震颤严重程度与不同幕下区域病变负荷之间的关系。在步数跟踪任务期间对震颤幅度进行量化。使用自动分割方法在磁共振图像上测量病变负荷。意向性震颤幅度与脑干的病变负荷显着相关，但与小脑的病变负荷无关。具体来说，震颤幅度与对侧脑桥的病变负荷相关，双臂震颤较严重的患者，双侧脑桥的病变负荷较大。这些结果支持多发性硬化症意向性震颤与小脑流入和/或流出通路功能障碍有关的观点。
Intention tremor due to multiple sclerosis is clinically similar to cerebellar tremor. This study investigated, in 14 multiple sclerosis patients, the relationship between intention tremor severity and the lesion load in different infratentorial regions. Tremor amplitude was quantified during step-tracking tasks. The lesion load was measured on magnetic resonance images using an automated segmentation method. Intention tremor amplitude was significantly related to lesion load in the brainstem but not in the cerebellum. Specifically, tremor amplitude correlated with the lesion load in the contralateral pons, and patients with more severe tremor in both arms had a greater lesion load bilaterally in the pons. These results support the view that multiple sclerosis intention tremor is related to dysfunction of cerebellar inflow and/or outflow pathways.