Isocyanide-based multicomponent reactions: catalyst-free stereoselective construction of polycyclic spiroindolines.
Isocyanide-based multicomponent reactions: catalyst-free stereoselective construction of polycyclic spiroindolines.
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DOI：
10.1021/ol400606c
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发表时间：
2013-04
期刊：
影响因子：
5.2
通讯作者：
Xiang Wang;Shun‐Yi Wang;S. Ji
中科院分区：
文献类型：
--
作者：
Xiang Wang;Shun‐Yi Wang;S. Ji
发展了一种新型的无催化剂一锅串联反应，用于多环螺环吲哚的立体选择性构筑。这种方法提供了一种直接获得结构多样的多环螺吲哚衍生物的方法，产率高(高达90%)，具有极好的非对映选择性。
A novel catalyst-free one-pot tandem reaction for the stereoselective construction of polycyclic spiroindolines was developed. This method offers a straightforward access to structurally diverse polycyclic spiroindoline derivatives in high yields (up to 90%) with excellent levels of diastereoselectivity.