THE MORPHOLOGY AND CELL-KINETICS OF PSEUDOPYLORIC GLANDS
THE MORPHOLOGY AND CELL-KINETICS OF PSEUDOPYLORIC GLANDS
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DOI：
10.1007/bf02892834
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
GEDIGK, P
中科院分区：
文献类型：
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作者：
HATTORI, T;HELPAP, B;GEDIGK, P
通过冷冻手术在大鼠胃底粘膜中形成粘膜缺损。术后50、100和200天研究再生粘膜的形态和细胞动力学。在所有3个时间点，粘膜缺损均被再生上皮完全覆盖。再生的粘膜主要由粘液腺结构组成，即使术后200天仍保持假幽门型。假幽门腺由两种不同类型的细胞组成，即含粘蛋白的细胞和内分泌细胞。前一种细胞类型缺乏典型粘液细胞的特征，而是具有介于粘液细胞和浆液细胞之间的细胞学特征，并且它们类似于真正的幽门腺或布伦纳腺细胞。通过 3 H-胸苷放射自显影显示，这些假幽门腺的粘液浆液细胞是由局限于峡部区域的增殖细胞产生的。它们的半衰期估计为 5-6 天。如果再生的腺体结构中的细胞更新达到稳定状态，它们就会不断更新；在此基础上，提出假幽门腺可能是胃底区域溃疡和粘膜再生后的持久粘膜结构。
A mucosal defect was made cryosurgically in the mucosa of the fundus of the rat stomach. The morphology and cell kinetics of the regenerated mucosa were studied 50, 100 and 200 days after operation. At all 3 time points the mucosal defect was completely covered with the regenerated epithelium. The regenerated mucosa was composed mostly of mucinous glandular structures and remained of a pseudopyloric type even 200 days after operation. The psuedopyloric glands consisted of 2 different kinds of cells, mucin-containing cells and endocrine cells. The former cell type lacked the characteristics of typical mucous cells, having instead cytological features intermediate between those of mucous and serous cells and they resembled true pyloric gland or Brunner''s gland cells. By 3H-thymidine autoradiography it was shown that the mucous-serous cells of these pseudopyloric glands are produced from proliferating cells confined to the isthmus region. Their half life was estimated to be 5-6 days. If cell turnover reaches a steady state in the regenerated glandular structures, they would be renewed continuously; on this basis it is suggested that pseudopyloric glands may be persistent mucosal structures in the fundic region of the stomach following ulceration and mucosal regeneration.